prediction of rejection in renal transplantation by immune parameters
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abstract
background: monitoring of phenotypic characteristics of t-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients. objective: to predict rejection in renal transplantation by immune parameters. methods: 16 non-diabetic kidney transplant candidates (4 females and 12 males, age = 20-65 yr, first time transplant) were selected. the transplanted patients were divided into two groups based on the rejection during 3 weeks post transplant: group i (n = 9) without rejection and group ii (n = 7) with a rejection episode. immune parameters including lymphocytes subpopulations (by flowcytometry) and immunoglobulin classes (igm, igg, iga and ige by nephlometric assay) before and 45 days after transplantation were determined. results: the results of this investigation showed that the level of immunoglobulin igg, igm, iga and ige decreased post transplantation due to immunosuppressive drugs. cd3, cd4, cd8 t cells count, cd56 nk cells count and cd20 b cells count pre- and post-transplantation did not show any significant differences. the amount of ige (220 vs. 462 iu/ml), cd3 (62% vs. 69.7%) and cd4 (35% vs. 41.3%) cells increased in group ii during rejection episode pre-transplantation. in addition, iga increased pretransplantation in group i those without rejection episode in comparison with group ii with a rejection episode. forty five days post transplantation iga (209 vs. 152 mg/dl), igg (1009 vs. 703 mg/dl) and cd20 (15% vs. 10%) increased in group i patients. conclusion: it is suggestive that pre-transplantation increases ige, cd3 and cd4 are predictive of acute rejection.
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Journal title:
iranian journal of immunologyجلد ۲، شماره ۲، صفحات ۸۷-۹۰
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